Coumarins and derivatives
Cayman Chemical CoumarIn hydrazIn 25mg
An aromatic hydrazine-containing fluorophore that reacts with aldehydes or ketones for fluorescent labeling; acts as a sensor for oxidative stress by detection of carbonylated biomolecules in live cells; ex/em = 365/430-550 nm; produces a red shift in emission upon hydrozone formation; displays a large Stokes shift of approximately 195 nm
Medchemexpress LLC 3-aminocoumarin (3-aminochromen-2-one) | 1635-31-0 | MFCD00016965 | 161.16 g/mol | C9H7NO2 | 1 G
3-Aminocoumarin (3-aminochromen-2-one) is an organic intermediate commonly used in coordination chemistry and organic synthesis as a precursor to ligands and metal complexes. Supplied for research use, it is intended for preparative and exploratory synthesis workflows where a well-characterized coumarin derivative is required.
- Serves as an intermediate for synthesis of metal complexes and ligands.
- Suitable for coordination chemistry and related organic synthesis applications.
- Characterized small molecule: formula C9H7NO2, molecular weight 161.16 g/mol.
- Recommended storage: 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
- Intended for research use only.
Accela Chembio Inc MF: C14H15NO4 | MW: 261.27 | ?97% | BP: 438.2? at 760 mmHg.
MF: C14H15NO4 | MW: 261.27 | ?97% | BP: 438.2? at 760 mmHg.
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 10mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
Medchemexpress LLC MTX-531 | 2791417-66-6 | 99.9% | 453.94 | 50 MG
MTX-531 is an oral drug that inhibits EGFR and PI3K, demonstrating anti-tumor effects. It also acts as a weak agonist of PPARγ, helping to alleviate hyperglycemia induced by PI3K inhibitors.
- Inhibits epidermal growth factor receptor.
- Inhibits phosphoinositide 3-kinase.
- Demonstrates anti-tumor effects.
- Acts as a weak agonist of peroxisome proliferator-activated receptors.
- Helps alleviate hyperglycemia.
- Suppresses tumor proliferation.
Medchemexpress LLC Coumarin 6 | 38215-36-0 | 1 ML
Coumarin 6 is a fluorescent dye utilized as a fluorescent probe within microparticle drug delivery systems. It is employed to conduct in vivo tracking, cellular uptake studies, and investigations into the transport mechanisms of drug delivery systems. It has an excitation wavelength (λexc) of 450 nm and an emission wavelength (λem) of 505 nm. This product is intended for research use only and is not sold to patients.
- Used for in vivo tracking, cell uptake, and transport mechanism studies in drug delivery systems
- Optimal wavelengths: Excitation at 450 nm and emission at 505 nm
- Purity: 99.59%
Indofine Chemical 7-Diethylaminocou, 98%, 250 Mg
7-DIETHYLAMINOCOUMARIN 250 MG, Coumarin, C13H15NO2, MW: 217.27, 98%, 20571-42-0, MFCD00232946
Medchemexpress LLC Coumarin 480 | 41267-76-9 | MFCD00041844 | 100.0% | 255.31 g/mol | C16H17NO2 | 25 MG
Coumarin 480 (Coumarin 102) is a high-purity fluorescent laser dye used in fluorescence spectroscopy, laser applications, and optical research. It shows strong emission near 480 nm and is supplied as a research-grade reagent for imaging, sensor development, and photophysical studies. Users should follow the product SDS for safe handling and storage.
- High purity (99.95%).
- Strong fluorescence emission near 480 nm.
- Suitable for fluorescence spectroscopy and laser dye applications.
- Useful for sensor development and imaging studies.
- Provided as a research reagent in small vials.
Medchemexpress LLC 7-Methylcoumarin | 2445-83-2 | MFCD00006880 | 5 G
7-Methylcoumarin is a coumarin derivative known for its potent hepatoprotective and antioxidant properties. It functions as a mechanism-based inhibitor for CYP2A6, a key enzyme involved in drug metabolism. Studies have shown that it can significantly reduce markers of liver damage, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB), in models of CCl4-induced liver injury. Additionally, it helps to restore total protein (TP) and albumin (TA) levels and prevent oxidative stress. It also exhibits an ability to decrease the mitotic activity of *A. sativum* promeristem.
- Possesses potent hepatoprotective properties
- Acts as a mechanism-based inhibitor for CYP2A6
- Reduces markers of liver damage
- Restores protein and albumin levels in serum
- Prevents oxidative stress
- Decreases mitotic activity
Medchemexpress LLC 3-Nitrocoumarin | 28448-04-6 | 100.0% | 191.14 | 1 ML
3-Nitrocoumarin is an inhibitor for phospholipase C that blocks the generation of inositol triphosphate (IP3), thereby affecting the calcium signaling pathway. This compound causes morphological changes of apical hyperbranching in *N. crassa* hyphae.
- Inhibits phospholipase C, affecting the calcium signaling pathway.
- Inhibits glucose-induced increase of intracellular calcium ions in yeast strain WPY260 (at 50 mg/mL for 6 min).
- Inhibits PLC in *Neurospora crassa* with an IC50 of 10 μg/mL.
- Inhibits the growth of *N. crassa* and causes morphological changes of apical hyperbranching in hyphae.
Cayman Chemical 4-HydroxycoumarIn 100g
A coumarin; inhibits vitamin K1 epoxidation and prothrombin synthesis by 18 and 67%, respectively, in cell-free assays at 6.2 mM; has been used in the synthesis of anticoagulants, as well as antithrombotic, anti-inflammatory, antibacterial, and antifungal agents
Indofine Chemical 5,6,7,3',4'-Pentame, 98%, 5 Mg
5,6,7,3',4'-PENTAMETHOXYFLAVONE, Flavonoid & Coumarins, 2306-27-6, 98%, 5 mg
TARGETMOL CHEMICALS INC 3-Nitrocoumarin 25MG
Also available in 1 mL, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. 3-Nitrocoumarin (3-nitrochromen-2-one) (3-NC) is a potent and selective Phospholipase C-gamma (PLCgamma) inhibitor. Purity 97.28%